On the cover: Chromatin structure regulates gene transcription and cellular differentiation. Matsumura et al. (pp. 584–596) show H3K4/H3K9me3 bivalent chromatin domains keep key developmental genes in a poised state for activation and restrict the differentiation potential of preadipocytes. Alice (Pol II) stops just before a barrier of cards of nine (H3K9me3) near a thin rabbit (meaning pause of adipogenic program), while when the barrier is removed, she starts running toward a fat rabbit (meaning active adipogenic program). Cover artwork credits: Space-Time Inc., Sofa Graphic Design.